Combination Drugs

Midazolam and Ketamine – an Ideal Combination

Midazolam is an FDA-approved benzodiazepine, first introduced in the U.S. market in 1997. It is commonly administered through the intravenous or intramuscular routes for conscious sedation, anxiolysis, and amnesia. Midazolam can also be administered orally as a syrup for pediatric patients.1

Ketamine was FDA-approved in 1970 as a rapidly acting, nonbarbiturate, general anesthetic. Ketamine is known to produce sedation, catalepsy, somatic analgesia, bronchodilation, amnesia, and sympathetic nervous system stimulation with a short recovery period. Distinct from other anesthetics, ketamine preserves the airway reflexes and has minimal effect on respiratory drive.1,2

Combining midazolam and ketamine produces the ideal anesthetic that alleviates anxiety, causes amnesia, manages pain, and facilitates a cooperative and stationary patient. The combination also provides cardiovascular stability and maintenance of respiratory reflexes, coupled with rapid recovery and minimal side effects.2


What People Are Saying

“I thought it was amazing. I was able to hold still, I didn’t feel anything or pay attention to anything, and surgery was over within what seemed like just a few minutes. When I got back to the recovery room, I was ready to go, went to lunch later that day and felt fine.”

Kenneth Beckman, MD refers to his experience with a compounded version similar to Melt-3003


  1. Tobias JD, Leder M. Procedural sedation: A review of sedative agents, monitoring, and management of complications. Saudi J Anaesth. 2011;5(4):395-410. doi:10.4103/1658-354X.87270
  2. Jeffries M, Bender C. Non-IV Sedation And the MKO Melt. Presented at the: Ophthalmic Anesthesia Society 32nd Annual Scientific Meeting; September 29, 2018; Chicago, IL. Accessed October 1, 2019.
  3. Beckman K. I had Cataract Surgery, and Here’s What Happened. Cataract & Refractive Surgery Today. (November/December 2019):30-31.