CURRENT INDICATION: PROCEDURAL SEDATION AND ANALGESIA PRIOR TO CATARACT SURGERIES
Our lead program, Melt-100, is a rapidly dissolving sublingual tablet, providing needle and opioid-free, patented formulation for procedural sedation and analgesia during cataract surgery — a growing field with significant market opportunity. In 2019, 4.2 million cataract surgeries were performed, and the number of surgeries is growing at approximately 3% per year.1,2
A cataract is clouding of the lens of the eye, preventing clear vision and leading to blindness if left untreated.3 Cataract removal is one of the most common, safest, and effective surgeries performed in the United States.4 With surgery times of less than one hour and exceptional results, cataract surgery is considered one of the most successful treatments in all of medicine.5 Progressing to sublingual sedation may be the next step in safety and comfort for a growing patient demographic.6
BENEFITS OF MELT-100 FOR CATARACT SURGERY
- Eliminate the need for IV delivered sedation/analgesia in the vast majority of patients.
- Eliminates pain and bruising for patient (needle stick is often the most painful and anxiety inducing part of the procedure.)
- 30% of patients given opioids pre-operatively for procedural sedation and analgesia in cataract surgery
- Over 50% patients given opioid at some point during cataract surgical procedure
- Potential for a more efficient operational flow through decreased preparation time for each patient.6
POTENTIAL TO ELIMINATE THE NEED FOR IV
WHAT PEOPLE ARE SAYING
“Cataract surgery has advanced over the last 2 decades, but our approaches to ocular anesthesia haven’t… I am excited to see innovation in this field as we try to create more patient friendly solutions that can be needle and opioid-free.”
Maggie Jeffries, MD, board certified anesthesiologist (Houston)
- Market Scope. US Cataract Quarterly Update: Q3 – 2019 Analysis of Historical Trends and Latest Developments.; 2019:1-37.
- Market Scope. Cataract Quarterly Update: Q3 – 2018.; 2018:1-38.
- WHO | Priority eye diseases. WHO. http://www.who.int/blindness/causes/priority/en/. Accessed July 28, 2019.
- Facts About Cataract | National Eye Institute. https://nei.nih.gov/health/cataract/cataract_facts. Accessed July 28, 2019.
- Davis G. The Evolution of Cataract Surgery. Mo Med. 2016;113(1):58-62.
- William F. Wiley MD. IV-free sedation may help anxious cataract patients. Ophthalmology Times. https://www.ophthalmologytimes.com/ article/iv-free-sedation-may-help-anxious-cataract-patients. Published July 15, 2016. Accessed July 28, 2019.
- Recent results from Ophthalmology Anesthesiology Society (OAS) survey in cataract surgery (2020)